Did Linus Pauling Invent a Cure for Angina & Heart Disease?

Published: 11th May 2006
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Did Linus Pauling Invent a Cure for Angina & Heart Disease?

In 1990 Dr. Linus Pauling was awarded a patent for his
therapy that, he claimed, could prevent and cure
atherosclerosis by using oral or intravenous dosages of
vitamin C, other antioxidant vitamins, and amino acids.

Dr. Pauling's research discovered that atherosclerosis
starts with mechanical damage to the coronary arteries.
Because these arteries are so close to the heart, they
undergo tremendous pressure swings that force them to expand
and contract each time the heart beats. This stress
inevitably results in damage to the lining of the coronary
arteries. This is not a problem if the body has the
resources available to make the proper repairs. But, if the
body runs out of these resources, it can not make the proper

Blood vessels are make strong and flexible with a connective
tissue protein called collagen. The proper repair to the
damaged coronary arteries, therefore, is to make more
collagen. In order for the body to make collagen it has to
have certain nutrients. A nutritional deficiency impairs the
body's ability to make enough collagen, and thus prevents
it from making the proper repairs. Leaky coronary arteries
would be very dangerous.

But Dr. Pauling discovered that the human body is very
smart. If it can not make the proper repairs, it does the
next best thing. The body takes whatever is handy
(cholesterol, fibrinogen, calcium) and fashions a patch over
the damaged portion of the artery. Disaster averted! But
mechanical stress is inevitable, so more damage will occur.
A continuing nutritional deficiency will necessitate larger
and thicker patches as time goes on. Until one day - the
coronary arteries will let their owner know they have a
problem via angina pain or a heart attack.

Dr. Pauling's research discovered that 4 vitamins and 3
amino acids were needed to maintain healthy coronary
arteries. He also discovered that these same substances,
when given in therapeutic doses, would reduce and (in some
cases) completely dissolve the atherosclerotic plaque
deposits within the coronary arteries.

If Dr. Pauling is right, the cure for atherosclerosis is
right under our noses. It's called The Mouth

For prevention, Dr. Pauling recommened the following (all
doses are per day):

Vitamin C (ascorbate) 3000 mg
Vitamin E (d-alpha-tocopherol) 400 mg
Vitamin A (Palmitate) 8000 IU
Coenzyme Q-10 100 mg
L-Lysine 3000 mg
L-Proline 250 mg
L-Carnitine 250 mg

For those who already have heart disease, Dr. Pauling
recommended the above dosages be doubled. None of these
substances are toxic at these levels. The worst side effect
of taking too much vitamin C is diarrhea. If this occurs you
could always cut back to a dosage that is tolerable.

Is there proof that the Pauling Therapy works? Yes, maybe,
and yes.

The First Yes

In a paper entitled, Nutritional Supplement Program Halts
Progression of Early Coronary Atherosclerosis Documented by
Ultrafast Computed Tomography and published in Vol. 48 of
the Journal of Applied Nutrition (pp 68-78, 1996), Dr. Rath
and Dr. Niedzwiecki reported the results of a yearlong study
on the effect of the Pauling Therapy on the natural
progression of coronary artery disease. Before the
intervention, the natural progression rate of the coronary
artery calcification averaged 44% per year. During the year
of treatment, however, the progression of coronary artery
calcification decreased by an average of 15%. In a subgroup
of patients with early stages of coronary artery disease,
treatment resulted in a statistically significant decrease,
with no further progression of coronary calcification. In
individual cases, reversal and complete disappearance of
previously existing coronary calcification were documented.

Similar results were obtained by Dr. K. Kenton in London
with a 3-year clinical trial of 200 males (soon to be
published study). Plaque growth progression was nearly
halted to about 2-3% per year in comparison with natural
progression in the control group of 15-30%. Or put another
way, plaque growth was 800-1500 % smaller in the group
taking the Pauling Therapy. [Email from Dr. K. Kenton dated
Wed, 5 Mar 2003 17:53:32]

There are also three case histories in the medical
literature attesting to the Pauling Therapy curing angina

1) Case Report: Lysine/Ascorbate-Related Amelioration
of Angina Pectoris Linus Pauling, Journal of Orthomolecular
Medicine, 6(3-4): 144-46, 1991.

2) A Case History: Lysine/Ascorbate- Related Amelioration Of
Angina Pectoris, M. McBeath & L. Pauling Journal of
Orthomolecular Medicine, 1993, 8: 77-78.

3) Cardiovascular Disease: A Unified Theory of the Cause and
Treatment, Institute for Optimum Nutrition, Video Tape, 1993.


Although these reports are intriguing, scientific proof
requires more than two studies and 3 case reports.

The Second Yes

G. C. Willis (1957), K. R. Sebrov (1956), W. J. McCormick
(1957), R. O. Mumma (1968), R. O. Mumma and A. J.
Verlangieri (1971), E. Ginter (1969), and C. R. Spittle
(1971) all demonstrated that, when vitamin C levels in the
blood are elevated, atherosclerotic plaque deposits begin to
disappear. And in 1974, C. Krumdieck and C. E. Butterworth
obtained a 60% reduction of plaque deposits using nothing
but oral doses of Vitamin C.

For 30 years (from the 40's to the late 70's) the Canadian
medical doctors Wilfrid E. Shute and Evan V. Shute
successfully treated over 30,000 heart disease patients with
vitamin E megadose therapy.

And these studies are just the "tip of the iceberg." There
are thousands of studies in the medical literature that
document the positive cardiovascular effects of the
individual nutrients that comprise the Pauling Therapy.

Sixty years after the Shute brothers began using vitamin E
and 13 years after Dr. Pauling published his first paper on
the Pauling Therapy - I believe it is fair to ask the

Why hasn't the medical community conducted more research
into this possible nutritional cure for atherosclerosis?


Ginter, E. et al (1969) The Effect of Chronic
Hypovitaminosis C on the Metabolism of Cholesterol and
Atherogenesis, Journal of Atherosclerosis Research, vol. 10,

Krumdieck, C. and Butterworth, C. E., Jr. (1974) Ascorbate-
Cholesterol-Lecithin Interactions: Factors of Potential
Importance in the Pathogenesis of Atherosclerosis, American
Journal of Clinical Nutrition, 27: 866--876, August.

McCormick, W. J. (1957) Coronary Thrombosis: A New Concept
of Mechanism and Etiology, Clinical Medicine, 839-845.

Mumma R. O. (1968) Ascorbic Acid as a Sulfating Agent,
Biochimica et Biophysica Acta, Vol. 165, 571-573.

Mumma R. O. and Verlangieri A. J. (1971) In Vivo Sulfation
of Cholesterol by Ascorbic Acid 3-Sulfate as a Possible
Explanation for the Hypocholestemic Effects of Ascorbic
Acid, Federation Proceedings, vol. 30, No. 2.

Sebrov, K. R. (1956) Prophylaxis and Treatment of
Arteriosclerosis with Ascorbic Acid, Terapevticheskii Arkhiv
(Moskva), Vol. 28, 55-65.

Shute, Evan (1969) Your Heart & Vitamin E, London, Canada:
The Shute Foundation for Medical Research.

Shute, Wilfrid E. (1969) Vitamin E for Ailing and Healthy
Hearts, New York: Pyramid House.

Spittle, C. (1971) Atherosclerosis and Vitamin C, Lancet,

Willis, G. C. (1957) The Reversibility of Atherosclerosis,
Canadian Medical Association Journal, 77:106-109.

About the author: Ray Ellis is in the process of collecting
all published scientific documents regarding the effect of
nutrition on heart disease in order to make this information
easily and freely available to the public. For more
information on this subject, you can visit his website at

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